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ÀÌ Á¦ È£ (Je-Ho Lee, M.D., Ph.D.)
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PRESENT POST
Director
Molecular Therapy Research Center
sponsored by Ministry of Science & Technology
of the Korean Government
Professor
Department of Obstetrics & Gynecology
Samsung Medical Center
Sungkyunkwan Univ. School of Medicine
Seoul, Korea
E-Mail : jeholee@gmail.com
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EDUCATION / POST GRADUATE TRAINING
1973 : M.D. Seoul National University, Seoul, Korea
1979 : M.S. (Medicine), Seoul National University, Seoul, Korea
1984 : Ph.D. (Medicine) Seoul National University, Seoul, Korea
1976 - 1977: Rotating Internship, Seoul Nat'l Univ. Hospital,
Seoul, Korea
1977 - 1981: Residency in Ob & Gyn., Seoul Nat'l Univ. Hospital,
Seoul, Korea
APPOINTMEMTS / WORK EXPERIENCE
1981 - Feb. 1994 :
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Senior Gynecologist
Department of Obstetrics & Gynecology |
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Director
Laboratory of Biochemistry & Molecular Genetics
Korea Cancer Center Hospital, Seoul, Korea
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1987 - 1989 :
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Postdoctoral Fellow, M.D. Anderson
Cancer Center
Houston, Texas
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May 1993 - Aug.1993 :
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Visiting Fellow, M.D. Anderson
Cancer Center
Houston, Texas
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Mar.1994 - Jun. 1998 :
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Director, Center for Clinical
Research
Samsung Biomedical Research Institute, Seoul, Korea
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Mar. 1994 - Mar. 2001 :
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Professor & Chairman
Department of Obstetrics & Gynecology
Samsung Medical Center
SungKyunKwan Univ. School of Medicine
Seoul, Korea
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Feb. 1999 - Oct. 2000 :
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Associate Director
Clinical Research Institute
Samsung Medical Center
SungKyunKwan Univ. School of Medicine
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Nov. 2000 - Aug. 2001 :
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Director
Clinical Research Institute
Samsung Medical Center
SungKyunKwan Univ. School of Medicine
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Feb. 1999 - Aug. 2001 :
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Director
Gene Therapy Research Center
Samsung Medical Center
SungKyunKwan Univ. School of Medicine
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July 2000 - present :
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Director
Molecular Therapy Research Center
sponsored by Ministry of Science & Technology
of the Korean Government
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OTHER PROFESSIONAL APPOINTMENTS & ACHIEVEMENTS
1994 - present :
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Executive
member of Biomedical Science in R & D
Committee Nat'l Council for Science and Technology
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1994 - 2000 :
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Chairman,
Samsung Annual International Symposium
Organizing Committee of the Samsung Biomedical
Research Institute
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| 1996 - present
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- Editor-in-Chief,
Journal of Genetic Medicine
- Vice President, Korean Society of Medical Genetics
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1997 - present
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- Leading Initiator
of the Telemedicine between M.D.
Anderson Cancer Center in Houston, Texas and
Samsung Medical Center in Seoul, Korea
- Founder and Chairman, Korean Society of Gene Therapy
- Chairman, GeneMed Network : Cyber Gene Therapy
Information Service Network
- President, ATI (Angel Technology & Information:
Non-profit Cyber Health & Biomedical Technology
Consulting Service Network)
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1998 - present
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- Founding Member,
International Molecular Biology Network
(IMBN) for Asia and Pacific Rim
- Editorial Board Member, Journal of Human Genetics
(Official Journal of the Japan Society of Human Genetics)
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| 1999 - present : |
Member, National Advisory Committee of Molecular
Medicine, Ministry of Science & Technology of Korea
Member, National Advisory Committee of Medical Research,
Ministry of Health & Welfare of Korea
Member, National Selection Committee of Medical Research
Projects, Ministry of Education of Korea
Representative Member, Korea-America Medical Research Forum,
OSTP (Office of Science & Technology Policy) of White House,
USA and STEPI (Science & Technology Policy Institute) of
Korea
Member, Research & Development Sub-Committee of the National
Science & Technology Committee, Ministry of Science & Technology
of Korea
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2000 - present
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- Executive Member of National
Council of Bioethics
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2001 - present:
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- Member, Nanotechnology
Committee, Ministry of Science
& Technology of Korea |
Special Note:
My research paper titled "Allelotype of human ovarian cancer.
Cancer Research (USA), 51:5118-5122, 1991" was one of the
10 most frequently referred and quoted Korean research papers
in overseas (acknowledged by the Ministry of Science & Technology
of Korea in 1998).
LICENSURE
1973 :
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Licensed Medical Doctor (No.13276),
Korean Society of Medical
Association
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1973 :
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ECFMG Certificate (USA)
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1981 :
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Certified Gynecologist (No.1244),
Korean Society of Obstetrics &
Gynecology |
PROFESSIONAL ORGANIZATION MEMBERSHIPS
- Member, American Society of Gene Therapy, 1998-
- Member, American Association of Cancer Research
- Member, International Society for Differentiation & Development
- Member, International Gynecologic Cancer Society, 1991-
- Member of the Korean Association of Obstetricians & Gynecologists, 1981-
- Member of the Korean Association of Cancer Prevention, 1996-
- Member of the Korean Society of Gynecologic Oncology and Colposcopy, 1992-
- Member of the Korean Cancer Association, 1981-
- Member of the Korean Society of Gynecologic Endoscopy, 1989-
- Member of the Korean Society of Ultrasound in Obstetrics & Gynecology, 1997-
RESEARCH ACTIVITIES
| 1989
-1994 : |
Project Director |
| Research Project on Molecular
Genetics of Malignant Tumors |
Ministry of Science & Technology
of the Korean Government
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| 1997
- 1999 : |
Principal Investigator |
| Human Genome Project |
Ministry of Science & Technology
of the Korean Government
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| 1991
- 2000 : |
Visiting Scientist |
| Research Project
on Molecular Genetics of Gynecologic Tumors |
Seoul National University
Cancer Research Institute
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| 1994
- 2002 : |
Principal Investigator |
| G-7 Research Project on Gene Therapy
of Malignant Tumors |
Ministry of Science & Technology
of the Korean Government
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| 2000
- present : |
Director |
| Molecular Therapeutics
Research Center |
| sponsored by Ministry
of Science & Technology of the Korean Government |
PUBLICATIONS IN INTERNATIONAL PEER-REVIEW JOURNALS
- Kim JS, Lee SH, Cho YS, Choi JJ, Kim YH, Lee JH. Enhancement of the
Adenoviral Sensitivity of Human Ovarian Cancer Cells
by Transient Expression of Coxsackievirus and
Adenovirus Receptor (CAR). Gynecol Oncol 85(2):260-5, 2002.
- Park J, Park K, Kim S, Lee JH. Msx1
Gene Overexpression Induces G1 Phase Cell Arrest in Human Ovarian
Cancer Cell Line OVCAR3. Biochemical and Biophysical Research
Communications 281:1234-1240, 2001.
- Bae DS, Cho SB, Kim YJ, Whang JD, Song SY, Park CS, Kim DS,
Lee JH. Aberrant Expression
of cyclin D1 is Associated with Poor Prognosis in Early Stage
Cervical Cancer of the Uterus. Gynecologic Oncology 81:341-347,
2001.
- Lee SH, Cho YS, Oh SH, Choi JJ, Lee JH. Aberrant
expression of Smad4 results in resistance against the growth
inhibitory effect of transforming growth factor-beta in SiHa,
human cervical cancer cell line. Int J Cancer 94:500-507,
2001.
- Lee SH, Zhang W, Cho YS, Oh SH, Choi JJ, Lee JH.
Overexpression
of the Thymosin beta-10 gene in human ovarian cancer cells disrupts
F-actin stress fiber and leads to apoptosis. Oncogene 20:6700-6706,
2001.
- Kang-Park S, Lee JH,Shin JH, Lee YI. Activation
of IGF-II Gene by HBV-X Protein Requires PKC and p44/p42 Map
Kinase Signalings. Biochemical and Biophysical Research
Communications 283:303-307, 2001.
- Kang WK, Park C, Yoon HL, Kim WS, Yoon SS, Lee MH, Park K,
Kim K, Jeong HS, Kim JA, Nam SJ, Yang JH, Son YI, Baek CH, Han
J, Ree HJ, Lee ES, Kim SH, Kim DW, Ahn YC, Huh SJ, Choe YH,
Lee JH, Park MH, Kong GS, Park EY, Kang YK, Bang YJ,
Paik NS, Lee SN, Kim SH, Kim S, Robbins PD, Tahara H, Lotze
MT, Park CH. Interleukin
12 gene therapy of cancer by peritumoral injection of transduced
autologous fibroblasts: outcome of a phase I study. Human
Gene Therapy 12(6):671-84, 2001.
- Kim JS, Lee SH, Cho YS, Park K, Kim YH, Lee JH. Development
of a packaging cell line for propagation of replication-deficient
adenovirus vector. Exp Mol Med. 2001 Sep 30;33(3):145-9.
- Kim JS, Lee SH, Cho YS, Kim YH, Lee JH. Ectopic
expression of the coxsackievirus and adenovirus receptor (CAR)
increases susceptibility to adenoviral infection in the human
cervical cancer cell line, SiHa. Biochemical and Biophysical
Research Communications 288(1):240-244, 2001.
- Song MS, Park YK, Lee JH, Park K. Induction
of Glucose-regulated Protein 78 by Chronic Hypoxia in Human
Gastric Tumor Cells through a Protein Kinase C-r/ERK/AP-1 Signaling
Cascade. Cancer Research 61:8322-8330, 2001.
- Choi D, Lee E, Hwang S, Jun K, Kim D, Yoon BK, Shin HS, Lee
JH. The
biological significance of phospholipase C beta 1 gene mutation
in mouse sperm in the acrosome reaction, fertilization, and
embryo development. J Assist Reprod Genet. 2001 May;18(5):305-10.
- Choi DS, Yoon S, Lee EY, Hwang SS, Yoon BK, Lee JH.
The expression of pseudogene cyclin D2 mRNA in the human ovary
may be a novel marker for decreased ovarian function associated
with the aging process. J Assisted Reproduction and Genetics
18(2):112-115, 2001.
- Roh CR, Oh WJ, Yoon BK, Lee JH. Up-regulation of Matrix
metalloproteinase-9 in human myometrium during labour : a cytokine-mediated
process in uterine smooth muscle cells. Molecular Human Reproduction
6(1):96-102, 2000.
- Moon IJ, Lee Y, Kwak CS, Lee JH, Choi K, Schreiber
AD, Park JG. Target Site Search and Effective Inhibition of
Leukemic Cell Growth by Covalently-Closed Multiple Antisense
(CMAS)-Oligonucleotides to c-myb. Biochem J 346: 295-303, 2000.
- Choi DS, Lee EY, Yoon S, Hwang SS, Yoon BK, Lee JH.
Clinical
Correaltion of Cyclin D2 mRNA Expression in Human Luteinized
Granulosa Cells. J Assisted Reproduction and Genetics 17(10):574-579,
2000.
- Kim J, Hwang ES, Kim JS, You EH, Lee JH. Intraperitoneal
gene therapy with adenoviral-mediated p53 tumor suppressor gene
for ovarian cancer model in nude mouse. Cancer Gene Therapy
6(2):172-178, 1999.
- Park CS, Joo IS, Song SY, Kim DS, Bae DS, Lee JH.
An
Immunohistochemical Analysis Of Heat Shock Protein 70, p53,
and Estrogen Receptor Status in Carcinoma of the Uterine Cervix.
Gynecologic Oncology 74:53-60, 1999.
- Hwang ES, Kim J, Kim JS, Kao C, Ko SC, Chung L, Lee JH.
The effects of the adenovirus-mediated wild-type p53 delivery
in human epithelial ovarian cancer cell lines in vitro and in
vivo, Int J Gynecological Cancer 8:27-36, 1998.
- Shim C, Zhang W, Rhee CH, Lee JH. Profiling
of differentially expressed genes in human primary cervical
cancer by cDNA expression array. Clinical Cancer Research
4(12):3045-3050, 1998.
- Kim JH, Lee SH, Lee JH. Loss of heterozygosity on
chromosome 22q and 17p correlates with aggressiveness of meningiomas.
J Neuro-Oncology 40(2):101-106, 1998.
- Kim BG, Park SY, Kim JH, Lee JH, Lee ED, Lee KH, Park
KB, Lee BH, Kim KH. Relationship between squamous cell carcinoma
antigen levels and tumor volumes in patients with cervical carcinomas
undergoing neoadjuvant chemotherapy. Gynecologic Oncology 63:105-113,
1996.
- Park W, Choi JJ, Hwang ES, Lee JH. Identification
of a Variant Estrogen Receptor Lacking Exon 4 and its Coexpression
with Wild-type Estrogen Receptor in Ovarian Carcinomas.
Clinical Cancer Research 2:2029-2035, 1996.
- Lee JH, Kang YS, Park SY, Kim BG, Lee ED, Lee KH,
Park KB. Expression of CD44R1 Adhesion Molecule in Primary and
Metastatic Gynecologic Malignancies and Their Cell Lines. Int
J Gynecologic Cancer 5:193-199, 1995.
- Park SY, Kang YS, Kim BG, Lee ED, Lee KH, Park KB, Lee
JH. Loss of heterozygosity on chromosome 17p in human cervical
carcinomas. Cancer Genet Cytogenet 79:74-78, 1995.
- Lee JH, Kang YS, Park SY, Kim BG, Lee ED, Lee KH,
Park KB, Kavanagh JJ, Wharton JT. p53 Mutation in epithelial
ovarian carcinoma and borderline ovarian tumor. Cancer Genet
Cytogenet 85:43-50, 1995.
- Park SY, Kim BG, Kim JH, Lee JH, Lee ED, Lee KH, Park
KB, Lee BH, Kim KH. Phase I/II study of neoadjuvant intra-arterial
chemotherapy with mitomycin-C, vincristine, and cisplatin in
patients with stage lib bulky cervical carcinoma. Cancer 76(5):814-823,
1995.
- Lee JH, Kang YS, Park SY, Kim BG, Lee ED, Lee KH,
Park KB. p53 mutation is rare in human cervical carcinomas with
HPV-positive sequence. Int J Gynecologic Cancer 4:371-378, 1994.
- Sato T, Saito H, Morita R, Koi S, Lee JH, Nakamura
Y. Allelotype
of human ovarian cancer. Cancer Research 51:5118-5122, 1991.
- Lee JH, Kavanagh JJ, Wharton JT, Wildrick D, Blick
M. Frequent
loss of heterozygosity on chromosome 6q, 11, and 17 in human
ovarian carcinomas. Cancer Research 50:2724-2728, 1990.
- Lee JH, Kavanagh JJ, Wharton JT, Wildrick D, Blick
M. Allele
loss at the c-Ha-rasl locus in human ovarian cancer. Cancer
Research 49:1220-1222, 1989.
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Curriculum Vitae